Browsing by Subject "C07K 16/1271"

Now showing items 1-19 of 19

    • Collagen binding protein compositions and methods of use 
      Hook, Magnus; Patti, Joseph M.; House-Pompeo, Karen; Sthanam, Narayana; Symersky, Jindrich (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2001-09-11)
      Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of ...
    • Collagen-binding proteins from enterococcal bacteria 
      Rich, Rebecca L.; Kriekemeyer, Bernd; Owens, Rick T.; Hook, Magnus; Murray, Barbara E.; Nallapareddy, Sreedhar R.; Weinstock, George M. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2005-06-21)
      A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized ...
    • Collagen-binding proteins from enterococcal bacteria 
      Rich, Rebecca L.; Kriekemeyer, Bernd; Owens, Rick T.; Hook, Magnus; Murray, Barbara E.; Nallapareddy, Sreedhar R.; Weinstock, George M. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2009-12-29)
      A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized ...
    • Compositions And Use Of A Fibrinogen Binding Motif Present In EFB And COA For Therapeutics And Vaccines Against Staphylococcus Aureus 
      Koo, Ya-Ping; Hook, Magnus; Arora, Srishtee; Visai, Livia; Bertoglio, Federico; Hust, Michael; Meier, Doris (United States. Patent and Trademark Office; Texas A&M University. Libraries, 8/9/2022)
      The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery ...
    • Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use 
      Hook, Magnus; Xu, Yi; Speziale, Pietro; Visal, Livia; Casolini, Fabrizia; Patti, Joseph M.; Patel, Pratiksha; Domanski, Paul (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2007-07-10)
      Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus ...
    • Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof 
      Hook, Magnus; Ko, Ya-ping; Smeds, Emanuel; Ganesh, Vannakambadi K. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2012-10-02)
      The present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen ...
    • Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof 
      Hook, Magnus; Ko, Ya-Ping; Smeds, Emanuel; Ganesh, Vannakambadi K. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2021-06-22)
      The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in ...
    • Fibronectin binding protein compositions and methods of use 
      Hook,Magnus; Patti, Joseph M.; House-Pompeo, Karen L.; Speziale, Pietro; Joh, Danny; Mcgavin, Martin J. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2004-02-03)
      Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus ...
    • Fibronectin binding protein compositions and methods of use 
      Hook, Magnus; Patti, Joseph M.; House-pompeo, Karen L.; Speziale, Pietro; Joh, Danny; Mcgavin, Martin J. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2006-10-31)
      Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus ...
    • Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein 
      Patti, Joseph M.; Hutchins, Jeff T.; Hall, Andrea; Santos, Linda; Bowden, Maria; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2013-07-02)
      Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus ...
    • Multicomponent vaccines 
      Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2010-02-23)
      Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies ...
    • Multicomponent vaccines 
      Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2004-03-09)
      Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies ...
    • Multicomponent vaccines 
      Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2011-09-13)
      Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies ...
    • Polypeptides and polynucleotides from coagulase-negative staphylococci 
      Foster, Timothy J.; Mccrea, Kirk; Hook, Magnus A. O.; Davis, Stacy; Ni Eidhin, Deirdre; Hartford, Orla (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2003-10-21)
      Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative ...
    • Polypeptides and polynucleotides from coagulase-negative staphylococci 
      Foster, Timothy J.; Mccrea, Kirk; Hook, Magnus A. O.; Davis, Stacey; Ni Eidhin, Deirdre; Hartford, Orla (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2010-05-04)
      Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, ...
    • Proteins and polypeptides from coagulaslase-negative staphylococci 
      Foster, Timothy J.; Mccrea, Kirk; Hook, Magnus A. O.; Davis, Stacy; Nieidhin, Deirdre; Hartford, Orla (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2009-01-06)
      Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are ...
    • Staphylococcal immunotherapeutics via donor selection and donor stimulation 
      Patti, Joseph M.; Foster, Timothy J.; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2004-02-17)
      A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection ...
    • Targeting Of Ligand Binding Sites In ClfA 
      Ganesh, Vannakambadi K.; Hook, Magnus (United States. Patent and Trademark Office; Texas A&M University. Libraries, 9/20/2022)
      The present invention provides methods and compositions to reduce binding of fibrinogen to the ClfA in a gram positive bacterial infections using monoclonal antibody, a polyclonal antibody, an antigen-binding antibody ...
    • Treatment of Staphylococcus aureus infections utilizing antibodies that bind to fibronectin binding proteins 
      Hook, Magnus; Patti, Joseph M.; House-pompeo, Karen L.; Speziale, Pietro; Joh, Danny; Mcgavin, Martin J. (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2012-07-03)
      Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus ...